This monograph is structured to provide both theoretical insights and empirical data. The first chapter outlines the clinical and pathophysiological aspects of Eagle syndrome, while subsequent chapters examine the climatic and socio-cultural factors that influence its prevalence and course in Uzbekistan. Through a combination of literature review, case studies, and statistical analysis, the research aims to present a comprehensive understanding of the syndrome’s characteristics in the Uzbek population. The findings will also be used to propose practical recommendations for healthcare providers, policymakers, and the public to enhance the awareness, diagnosis, and management of Eagle syndrome in the country.